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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are often characterized by their focus on practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used different investigators and had participants from various geographical areas. This kind of heterogeneity is necessary for practical trials to be valid and also helps reduce the chance of bias in the results. However, too much heterogeneity can lead to problems with the design of the trial.

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Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are usually requested by practitioners and policy makers to guide their decision-making. They also provide a useful method of determining the causal relationship between an intervention and its outcomes. However, they should not be used in lieu for the use of explanation studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials can be used to replace explanation tests or 프라그마틱 슬롯 사이트 if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials, which guide the practice and policy decisions. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a practical trial, including recruitment, design and delivery of the intervention, as well as follow-up.

The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to note that the majority of these studies were conducted in primary care settings.