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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically described by their focus on practical aspects of designing a study which include recruitment and consent, adherence and the use of routinely available equipment.

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A pragmatic study that involves a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be valid, and it also helps reduce the chance of bias in the results. However, too much heterogeneity can result in problems with the design of the trial.

Pragmatic Play is one of the biggest players on the live casino market, provides various classic table games such as Blackjack and Roulette. The live studios of the company in Romania and Malta provide customers with an authentic experience in gambling as well a full variety of betting options via virtual. The company also hosts a variety of games that make online gambling more enjoyable and engaging. Some of these shows have live hosts, whereas others are hosted by famous personalities from the industry.

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Pragmatic Play is known for its top-notch games, and for offering an exceptional user experience. The software is available on mobile devices and in a variety of languages. Despite its relatively young age, it has already established itself as a premier gaming platform for casinos. The most recent releases include Wolves which is a five-reel video slot that has a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are usually commissioned by policymakers and practitioners in order to guide their decisions. They can also be a great method to determine the causal relationship between an intervention and its results. However, they shouldn't be used as a substitute for the use of explanation studies.

The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which support a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic trial, including the recruitment process, the design and implementation of the intervention, and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note that the majority of these studies were conducted in primary-care settings.