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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are usually characterized by a focus on the practical aspects of study design, such as the recruitment and consent process, adherence, and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from different geographic areas. This type of heterogeneity is required for practical trials to be valid and also helps reduce bias in the results. However excessive heterogeneity could cause problems with the design of the trial.

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The purpose of pragmatic trials is to replicate real-life situations and achieve maximum credibility externally. They are typically commissioned by policy makers and practitioners to inform their decision making. They also provide a useful method of determining the causal relationship between an intervention and its outcomes. They should, however, not be used to replace explanatory studies.

The pragmatism idea is controversial, and there are questions regarding whether pragmatic trials could replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials that inform the policy and 프라그마틱 사이트 공식홈페이지 (simply click the up coming webpage) practice of. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the elements of a pragmatic study that include the recruitment process, the design and delivery of the intervention, as well as monitoring.

There is a positive trend in the number of pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming more acquaint to the issue of pragmatism. It is important to note, however, that the majority of these studies were conducted in primary care settings.